Skip to main content

Reimagining Innovation and Investment in Prevention and Care Research

What are the research questions, incentives, and overlooked opportunities for innovation that hold the greatest potential to prevent disease and improve outcomes of care in the United States?

The United States has the worst health outcomes of any affluent country in the world. Why? Part of the answer lies in the nation’s incomplete investments in research-based innovations to prevent disease and to effectively deliver safe and efficient care to all patients. Existing investments have resulted in breakthrough discoveries leading to lifesaving treatments, but we still have an urgent need to complement this support with investments in innovative research to keep people from getting sick, and to ensure that sick people have the best possible outcomes from the care they receive. To do this, we need strong pathways to fund, conduct, and apply research in prevention and care that mirrors the way we approach research for treatments. By strengthening support for research focused on the prevention and improvement of outcomes for medical encounters, we can maximize the societal benefits of health research. 

Read more about the Doris Duke Foundation’s perspective.

Biomedical advances, like gene editing for sickle cell disease and immune therapies for cancers, have shown what modern medicine is capable of, yet many preventable diseases persist and clinical encounters can be improved to yield better outcomes. Research that could make a real difference doesn't always receive the necessary financial support or has the structures needed to translate breakthrough innovations into practice.

The Collective

The Doris Duke Foundation, together with American Cancer Society, American Heart Association, Burroughs Wellcome Fund, Dana Foundation, Donaghue Foundation, Prebys Foundation, Robertson Foundation, Susan G. Komen and additional philanthropic partners are the Collective to Strengthen Pathways for Health Research. The Collective is seeking to bring greater attention and resources for breakthrough health research to improve how we prevent and address disease. Our current activities are focused on elevating voices and ideas to help define an actionable blueprint for progress. In 2025, the Collective will convene a series of 18 nationwide conversations, designed to inform a blueprint for action that will encompass reimagined funding models, policy changes, innovative delivery approaches, systemic shifts and cross-sector investments that can produce transformative gains in health outcomes.

The Conversations

Arizona State University: Arizona Digital Health Symposium: Charting a Course for Advancing Digital Health

Association of American Medical Colleges: The Promise of Integrated Behavioral Health Care: Improving Health Outcomes

Dartmouth College and Dartmouth Health: Dartmouth Rural Health Symposium

Duke University: How Philanthropy and the Private Sector Can Positively Impact Human Health (Programmatic Track at the Duke-Margolis Institute’s Annual Health Policy Conference)

Emory University: Symposium on Prevention and Treatment of Chronic Disease in the Southeast: How do we motivate adoption of prevention-focused interventions into clinical care encounters?

Harvard Pilgrim Health Care Institute: Symposium to Strengthen Maternal Health Research

Johns Hopkins University Armstrong Institute for Patient Safety and Quality: Advancing Patient Safety and Healthcare Quality:  Linking Research, Policy, and Implementation

Mayo Clinic: Accelerating New Therapies to Patients – Combining Efficacy and Effectiveness in Clinical Trials of Broad Populations

Metropolitan Area Planning Council (MAPC) & Boston University: Fostering Collaborations: A Symposium to Advance Equitable Heat Health Actions

Morehouse School of Medicine: Connecting Research to Health Justice in Local Contexts: Community-Driven Research Priorities and Opportunities for Scalable and Sustainable Impact

NYU Grossman School of Medicine: Catalyzing Change Through Research: Building Learning Health Systems for Tomorrow

Puerto Rico Science Technology and Research Trust: Symposium for Advancing Precision-Based Integrative, and Individualized Healthcare in Puerto Rico

Social Science Research Council: Re-Engineering Health Decision-Making Environments

University of Alabama at Birmingham Heersink School of Medicine: Breaking the Boundaries: Reimagining Health Research and Clinical Practice for a Healthier Tomorrow

University of Chicago: Chicago CARE: Connecting and Aligning Research to Achieve Health Equity

University of Southern California: The United States Street Medicine Summit: Building a National Policy & Research Agenda

University of Utah: Extending Return on Investment: A Multi-Sector Approach to Whole-Person Health

Virginia Tech: Whole Health, Whole Community: Dialogues to Reduce Rural Health Disparities